Speakers of the Opening Ceremony of the Prague Student Summit XXII Season are:
- Eva Prudilová, Chief Coordinator of the Prague Student Summit
- Vlaďka Votavová, Director of the Association for International Affairs (AMO)
- H. E. Lubomír Zaorálek, Minister of Foreign Affairs of the Czech Republic
- H. E. Marie Chatardová, Czech Permanent Representative to the UN in New York
- Dana Kovaříková, Acting Head of the Representation of the European Commission in the Czech Republic
- Erik Tabery, Editor in Chief of Respekt
- Tomáš Zima, Rector of the Charles University
- Filip Jelínek, Deputy Chief Coordinator of the Prague Student Summit
- H. E. Martin Stropnický, Minister of Defence of the Czech Republic
- Hana Halfarová, Projects Director at The Kellner Family Foundation
- H. E. Jan Kára, Czech Permanent Representative to the UN in Geneva
- Taťána Gregor Kuchařová, Chairman of the Board of Trustees in Beauty of Help Foundation
- Magda Vášáryová, Sociologist, Politician and former Diplomat
- Kelly Adams-Smith, Chargé d’Affaires at the U. S. Embassy