The International Roundtable Seminar Russia, West and Security in Europe at the Beginning of the 21st Century was organized by the Association for International Affairs in cooperation with the Center for Eastern Studies (OSW) on 18 October 2010 in Prague. Based on the conference presentations and discussions, the prospects of a rapid and deep improvement of NATO-Russia relations are dim. Continuing differences in the perception of security and lingering mutual distrust prevent a development of a truly strategic partnership. However, this does not mean that progress is impossible.